- CasNo 10517-21-2
- Purity 99%
Location:Home > Agrochemicals
5-Chloroindole-2-carboxylic acid 10517-21-2 with purity >99% Low price in stock
- Molecular Formula: C9H6ClNO2
- Molecular Weight: 195.605
- Appearance/Colour: light pink to beige or light brown powder
- Vapor Pressure: 7.12E-09mmHg at 25°C
- Melting Point: 283-287 °C
- Refractive Index: 1.5790 (estimate)
- Boiling Point: 449.7 °C at 760 mmHg
- PKA: 4.26±0.30(Predicted)
- Flash Point: 225.8 °C
- PSA： 53.09000
- Density: 1.548 g/cm3
- LogP: 2.51950
5-Chloroindole-2-carboxylic acid(Cas 10517-21-2) Usage
InChI:InChI=1/C9H6ClNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)/p-1
10517-21-2 Relevant articles
Synthesis and Biological Evaluation of Indole-2-carbohydrazide Derivatives as Anticancer Agents with Anti-angiogenic and Antiproliferative Activities
Zhang, Jianqiang,Liu, Tongyang,Chen, Mei,Liu, Feifei,Liu, Xingyuan,Zhang, Jihong,Lin, Jun,Jin, Yi
, p. 1181 - 1192 (2018)
A novel series of indole-2-carbohydrazid...
Preparation method of indole-2-formic acid derivative
-
Paragraph 0046-0048, (2020/07/14)
The invention discloses a preparation me...
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors
Abdelrahman, Mostafa H.,Abdu-Allah, Hajjaj H. M.,Abou-Ghadir, Ola F.,Al-Wahaibi, Lamya H.,Ali, Asmaa T.,Farghaly, Hatem S.,Gouda, Ahmed M.,Salem, Ola I. A.,Trembleau, Laurent,Youssif, Bahaa G. M.
, (2020/09/15)
Recent studies have shown additive and s...
Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway
Shen, Qing-Kun,Deng, Hao,Wang, Shi-Ben,Tian, Yu-Shun,Quan, Zhen-Shan
, p. 15 - 31 (2019/04/10)
A series of novel oridonin derivatives b...
ANTIBACTERIAL COMPOUNDS
-
Page/Page column 86-89, (2019/11/04)
The present application provides compoun...
10517-21-2 Process route
-
-
4792-67-0
5-chloro-indole-2-carboxylic acid ethyl ester
-
-
10517-21-2
5-chloro-1H-Indole-2-carboxylic acid
Conditions
| Conditions | Yield |
|---|---|
|
With
water; sodium hydroxide;
In
ethanol;
at 40 ℃;
|
96%
|
|
5-chloro-indole-2-carboxylic acid ethyl ester;
With
sodium hydroxide;
In
methanol; water;
for 1h;
Reflux;
Green chemistry;
With
hydrogenchloride;
In
methanol; water;
at 40 ℃;
pH=3 - 4;
Green chemistry;
|
92.5%
|
|
5-chloro-indole-2-carboxylic acid ethyl ester;
With
sodium hydroxide;
In
ethanol;
for 3h;
Reflux;
With
acetic acid;
In
ethanol; water;
pH=5;
Cooling with ice;
|
90%
|
|
With
sodium hydroxide;
In
ethanol; water;
at 70 ℃;
for 2h;
|
89%
|
|
With
potassium hydroxide;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
|
|
|
With
sodium hydroxide;
In
ethanol;
for 3h;
Reflux;
|
|
|
With
water;
Alkaline conditions;
|
-
-
(Z)-4-(2,4-dichloro-benzylidene)-2-phenyloxazole-5(4H)-one
-
-
10517-21-2
5-chloro-1H-Indole-2-carboxylic acid
Conditions
| Conditions | Yield |
|---|---|
|
With
ethanol; sodium hydrogencarbonate; copper(I) bromide;
In
N,N-dimethyl-formamide;
at 20 - 140 ℃;
Reagent/catalyst;
Solvent;
Temperature;
|
76%
|
10517-21-2 Upstream products
-
4792-67-0
5-chloro-indole-2-carboxylic acid ethyl ester
-
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-
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4-chlorophenyldiazonium salt
-
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2-[(4-chlorophenyl)-hydrazono]-propionic acid ethyl ester
10517-21-2 Downstream products
-
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-
118427-38-6
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-
186429-59-4
(2S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid methyl ester
-
1053711-72-0
(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester
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